Revolution Health Radio

In this episode of Revolution Health Radio, Chris breaks down a new large-scale study challenging the popular belief that plant-based diets promote longevity. The findings reveal that vegetarians—especially vegans—were significantly less likely to reach age 100 compared to omnivores. Chris explores the biological reasons behind these findings, emphasizing the importance of high-quality protein and nutrient bioavailability, as well as why certain nutrients may be harder to obtain from plant-only diets. He also discusses the powerful nutritional synergy that occurs when plant and animal foods are consumed together, arguing against rigid dietary dogma and advocating for a balanced, omnivorous approach to support healthy aging and longevity. The post RHR: New Study Challenges the Plant-Based Longevity Myth appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris sits down with gastroenterologist and microbiome researcher Dr. Zain Kassam to explore the rapidly evolving science of the microbiome and its profound impact on sleep, circadian rhythm, cognitive performance, stress resilience, immune balance, and longevity. From groundbreaking research on microbiome diversity and sleep quality to emerging innovations like cobiotics, Dr. Kassam explains how our microbial partners regulate core biological systems far beyond the gut. They discuss the connection between the gut and the brain, eyes, skin, and even ears—along with practical strategies for supporting microbial health in a modern world that constantly disrupts it. The post RHR: Beyond the Gut: The Microbiome’s Role in Sleep, Energy, and Longevity, with Dr. Zain Kassam appeared first on Chris Kresser.

Depression and anxiety are often treated as chemical imbalances in the brain—but what if the real problem starts in the gut? In this episode of Revolution Health Radio, we dive deep into the gut–brain connection and the growing body of research linking gut inflammation, microbiome imbalance, and mood disorders. You’ll learn how inflammatory cytokines contribute to depression, why butyrate is emerging as a powerful antidepressant compound, and how specific probiotic strains can improve mental health outcomes. Chris also shares practical, evidence-based strategies—including diet, supplementation, and functional testing—to address root causes and support lasting emotional well-being. The post RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris Kresser explains why vitamin D supplementation should never be one-size-fits-all. Drawing on new research—including a groundbreaking study on magnesium’s regulatory role—Chris explores how genetics, ethnicity, body weight, age, health status, sun exposure, and nutrient cofactors all shape an individual’s vitamin D needs. He outlines optimal testing strategies, safe and effective target ranges, and the critical roles of magnesium, vitamin K2, and vitamin A in vitamin D metabolism. The episode reframes vitamin D optimization as a personalized, systems-based approach that prioritizes balance, testing, and real-world physiology over generic dosing guidelines. The post RHR: Vitamin D: Why a Personalized Approach Is Best appeared first on Chris Kresser.

Cold plunges and ice baths dominate social media, but do they really deliver the best metabolic benefits? In this episode of Revolution Health Radio, Chris Kresser challenges the “colder is better” narrative and explores what the science actually shows about cold exposure. Drawing on clinical research, he explains how brown adipose tissue works, why sustained mild cold exposure activates it more effectively than brief extreme cold, and how this can improve insulin sensitivity, glucose metabolism, and overall metabolic health. The post RHR: Cold Exposure: Why Sustained Beats Extreme appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris challenges the conventional focus on sleep duration and makes the case that sleep timing and circadian alignment matter just as much—if not more—than total hours slept. Drawing on new research, he explains how circadian disruption underlies poor sleep quality, chronic fatigue, and a wide range of mental health conditions, even in people who appear to be doing everything “right.” He explains why light exposure, sleep-wake consistency, and meal timing are the primary drivers of restorative sleep, why adolescents are uniquely vulnerable to sleep-related mental health risks, and shares practical strategies to improve sleep naturally and when supplements may be helpful. The post RHR: Why Your Sleep Schedule Matters As Much As Duration appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris examines research confirming that menopause-related brain fog is real, measurable, and reversible. He explains how gray and white matter changes, blood-flow disruption, inflammation, and declining estrogen impact cognitive function during perimenopause and menopause. He also highlights the critical role of the gut microbiome in regulating estrogen metabolism and influencing brain health, and provides listeners with a comprehensive, root-cause approach to improving memory, focus, and clarity through diet, exercise, stress management, sleep, targeted nutrients, and gut-supportive strategies. The post RHR: Menopause Brain Fog—What’s Really Happening (and How To Fix It) appeared first on Chris Kresser.

Seed oils have become one of the most controversial topics in nutrition, especially after a 2024 University of South Florida study linked high omega-6 levels with inflammation in colon tumors. In this episode of Revolution Health Radio, Chris takes a deep, evidence-based look at what the study actually means — and what it doesn’t. You’ll learn the crucial difference between naturally occurring omega-6 fats in whole foods like nuts, chicken, and avocados and oxidized omega-6 fats found in ultra-processed foods and industrial seed oils. He explains why awareness of the omega-6 to omega-3 ratio and the issues of the modern Western diet are far more important than demonizing individual oils and offers practical advice on which cooking oils to use, which to limit, how to improve omega-3 intake, and how to adopt a balanced approach to dietary fats without fear or obsession. The post RHR: Seed Oils and Colon Cancer – What the New Research Really Shows appeared first on Chris Kresser.

In this episode, Chris explains why obsession with anti-aging hacks may actually undermine our long-term health. He examines the common longevity traps people fall into, which foundational habits truly extend lifespan and health span, and outlines a simple framework for prioritizing what really works. If you’re overwhelmed by conflicting longevity advice, this episode brings clarity, realism, and a grounded path forward. The post RHR: The Longevity Trap: Why Chasing Anti-Aging May Be Aging You appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris welcomes psychiatrist Dr. Matt Bernstein to explore the emerging field of metabolic psychiatry, the science linking brain energy metabolism to mental health. They discuss how conditions like depression, bipolar disorder, schizophrenia, and anxiety often share a root cause in impaired brain energy production, and how ketogenic therapy can restore balance and improve outcomes where traditional treatments fall short. Chris and Dr. Bernstein also unpack the latest research, the mechanisms behind ketones’ impact on the brain, and practical considerations for adults, teens, and families exploring this approach. The post RHR: The Link Between Metabolic Health and Mental Well-Being, with Dr. Matt Bernstein appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris explores natural solutions for one of today’s most pressing challenges: chronic stress, anxiety, and poor sleep. He shares his top five nutrients for restoring calm and focus (saffron, L-theanine, lemon balm, holy basil, and ashwagandha), revealing how each supports the brain and body’s ability to relax, recharge, and build resilience. Drawing from both scientific research and clinical experience, Chris explains how these compounds balance neurotransmitters, reduce cortisol, and improve mood and sleep quality without sedation or dependence. Listeners will learn practical strategies for combining these nutrients safely and effectively to achieve steady energy, emotional balance, and deep, restorative rest. This episode offers a roadmap to move from wired and tired to calm and clear, using evidence-based tools rooted in both modern science and ancient wisdom. The post RHR: From Wired & Tired to Calm & Clear: My Top Nutrients for Mood, Focus, and Sleep appeared f

In this episode of Revolution Health Radio, Chris welcomes board-certified periodontist Dr. William Levine to discuss the overlooked role of gum health in systemic disease. They unpack how oral bacteria and chronic inflammation contribute to conditions like heart disease, dementia, autoimmune disorders, and pregnancy complications, and why periodontal health is as critical as diet and lifestyle in preventing chronic illness. Dr. Levine shares how to recognize early signs of gum disease, the latest approaches to treatment and prevention, and the importance of personalized care. The discussion highlights emerging technologies including laser therapy, PRP, photobiomodulation, and PEMF, offering a glimpse into the future of dentistry and frequency medicine. Listeners will come away with a deeper understanding of how maintaining oral health supports whole-body wellness and what promising innovations lie ahead. The post RHR: The Science Behind Oral Inflammation, with Dr. William Levine appeared first on Chris Kress

In this episode of Revolution Health Radio, we dive deep into the topic of beauty from within, exploring why radiant skin, hair, and nails truly start from the inside. Chris discusses how internal factors such as gut function, nutrient status, inflammation, blood sugar regulation, hormonal balance, and stress management are foundational to external beauty. He explains the science behind the gut-brain-skin axis, the role of inflammation and leaky gut in skin health, and how stress impacts our appearance. He also highlights six key nutrients that can significantly enhance skin hydration, elasticity, and overall appearance, and shares practical insights into incorporating these science-backed nutrients into your diet or supplementation routine, empowering you to support your natural beauty from the inside out. The post RHR: Beauty From Within – Why Radiant Skin, Hair, and Nails Start Inside appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris Kresser welcomes environmental wellness expert Michael Rubino for an in-depth conversation on the hidden health risks of indoor air pollution. They delve into why mold-related illness is more common than most people realize, how traditional mold testing methods often fail, and why household dust holds the key to understanding environmental exposure. Michael explains the concept of “clean breathing,” the impact of modern home construction on air quality, and how to assess your indoor environment using practical DIY tools. The discussion also covers overlooked threats like formaldehyde, VOCs, radon, and microplastics, as well as actionable strategies for remediation and improving ventilation. Finally, Michael offers essential advice for vetting professionals, avoiding costly missteps, and creating a healthier home environment for long-term well-being. The post RHR: Mold, Indoor Air Quality, and Clean Breathing, with Michael Rubino appeared first on Chris Kresser

In this episode of Revolution Health Radio, Chris Kresser welcomes food scientist and advocate for regenerative agriculture Dr. Frederic Leroy to discuss his groundbreaking work on the Nourishment Table, a new framework for assessing dietary adequacy. They explore why conventional dietary guidelines fail, how nutrient density and food processing deeply influence human health, and the evolutionary importance of animal-source foods in achieving optimal nutrition. Dr. Leroy highlights the limitations of popular nutritional models, sheds light on overlooked factors like bioavailability and organ meats, and addresses confusion surrounding plant-based diets and processed foods. Their conversation also covers practical tips for implementing this approach in everyday life and insights into navigating complex food policy and nutritional science debates. The post RHR: The Nourishment Table, with Frederic Leroy appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris Kresser welcomes entrepreneur and strategist Seth Spears for a wide-ranging conversation on health, resilience, and building businesses with purpose. They explore the origins of Seth’s wellness-focused companies, including Wellnesse and Rewild Gear, and how they challenge conventional thinking in personal care and outdoor lifestyle. Seth shares insights into the philosophy behind creating high-quality, mission-driven products and discusses the often-overlooked importance of oral health, environmental sustainability, and consumer awareness. The conversation also delves into the mental and physical health benefits of reconnecting with nature, raising resilient kids in a tech-saturated world, and embracing voluntary discomfort as a path to personal growth. The post RHR: Rediscovering Health, Nature, and Purpose-Driven Business, with Seth Spears appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris welcomes renowned neurologist Dr. Dale Bredesen back to the show for an insightful conversation about protecting and enhancing cognitive health throughout your lifetime. They discuss groundbreaking advances in Alzheimer's prevention and early detection, explore the latest diagnostic tools and assessment techniques, and review compelling evidence from recent clinical trials. Dr. Bredesen provides actionable advice on essential lifestyle strategies—including diet, exercise, and sleep—that significantly impact brain health. The episode also covers the strategic use of supplements and the role of brain stimulation therapies, equipping listeners with practical tools to optimize cognitive function and sustain brain health at any age. The post RHR: How to Sharpen and Protect Your Mind for a Lifetime, with Dale Bredesen appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris Kresser dives deep into the fascinating world of collagen, the most abundant protein in the human body. He explores collagen's wide-ranging benefits—from supporting vibrant skin, healthy hair, and strong nails, to improving joint health, muscle recovery, gut integrity, and sleep quality. Chris breaks down the science behind collagen supplementation, dispels common myths, and shares practical tips for choosing the best collagen supplements for your needs. The post RHR: Everything You Need to Know About Collagen appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris Kresser talks with Mark Sisson, author of Born to Walk and renowned figure in the ancestral health space, about rethinking our approach to fitness. They challenge the conventional wisdom of chronic cardio and explore the myriad benefits of walking as a foundational movement practice. Mark shares his insights on how modern footwear and a misunderstanding of our evolutionary biology have led us astray, and offers a refreshing perspective on how to optimize our movement for health, longevity, and enjoyment. The post RHR: Exploring Peak Health and Fitness, with Mark Sisson appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris Kresser unveils the world of Gut Health 3.0, a comprehensive approach that goes far beyond traditional probiotic supplementation. Drawing on the latest scientific research, Chris explores how polyphenols, bacteriophages, and postbiotics work together to optimize gut health, offering listeners a roadmap to improved digestion, mental clarity, metabolic function, and overall wellness. Through compelling case studies and in-depth scientific insights, this episode demonstrates how understanding and supporting our gut microbiome can be the key to transforming multiple aspects of our health. The post RHR: Gut Health 3.0- The Power of Polyphenols and Postbiotics appeared first on Chris Kresser.