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Tranexamic acid, which frustrates clot dissolution, has been shown to reduce death from intracranial bleeding in a large international placebo-controlled trial — “CRASH-3.” Ali Raja and Joe Elia host a lively chat with Ian Roberts, the co-chair of the trial’s writing committee, who, in addition to chastising the hosts’ seeming fascination with P-values, recounts a story from early in his training that first stirred his devotion to preventing bleeding-related death after trauma. NEJM Journal Watch Emergency Medicine summary of CRASH-3 CRASH-3 report in The Lancet Ian Roberts explains CRASH-3 on YouTube to collaborators in Malaysia Roberts presents CRASH-3 results at World Congress on Intensive Care on YouTube Running time: 23 minutes The post Podcast 242: Tranexamic acid saves lives after traumatic bleeds first appeared on Clinical Conversations.