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PPIs are back on our radar, and this time it’s their regular use among postmenopausal women. A BMJ article examines data from the Nurses’ Health Study to show a significantly increased risk for hip fracture among postmenopausal women with any smoking history. Never-smokers showed no statistically significant increase. Now that proton pump inhibitors have been available over-the-counter for the better part of a decade, should clinicians be asking about their patients’ smoking history in concert with asking about how they handle heartburn? Links: BMJ article (free) Physician’s First Watch summary (free) FDA’s May 2010 warning on PPIs and fracture risks (free) The post Podcast 144: Hip fractures, PPIs, and smoking history in postmenopausal women — increased risks first appeared on Clinical Conversations.