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Mike Palmer returns to the Thanksgiving table to serve up a side of applied neuroscience. Powered by the recently released Gemini 3, he examines the "gratitude cocktail," a potent neurochemical mix of dopamine, serotonin, and oxytocin that mimics the effects of antidepressants and strengthens social bonds. Beyond the chemistry, Mike explores the psychological framework of The Gap and the Gain by Dan Sullivan and Dr. Benjamin Hardy. He explains how measuring progress against an ideal future creates unhappiness, while measuring against the past generates resilience and satisfaction. The conversation shifts from theory to practice, detailing why gratitude stories are more effective than rote lists and how specific "Notice, Think, Feel, Do" protocols rewire the brain. Mike also debunks the tryptophan myth, explaining how carbohydrates and compelling narratives—like football—actually drive the post-meal nap. Finally, he reflects on the origins of Trending in Education, shares updates on the new Trending in Higher