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Epigenetic Inheritance: Dr. Mansuy Discusses Research on Trauma and Neuroepignetics

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Sinopsis

Neuroepigenetics entails processes that involve the neuro system. Dr. Isabelle Mansuy explains her research by exploring: How epigenetics determines cellular formation and is therefore fundamental in development. How life experiences can affect germ cells and how this is transmitted across generations. Why experiencing trauma at a young age will cause the strongest epigenetic effect. Dr. Isabelle Mansuy runs the Laboratory of Neuroepigenetics at the University of Zurich. Her lab is interested in the long-term effects of stress through the epigenetic carryover. Their studies on mice have shown that young individuals exposed to trauma at a very vulnerable time, a time when their germ cells are less protected, can retain dramatic effects. These stress-induced traumas modify the germ cell epigenome and the traces left on the brain sometimes carry over across generations. Through these studies, her lab has made a solid model that is reproducible where they can screen these epigenetic changes and plot whic